The nine Regional Enterprise Plans are an integral part of Ireland’s enterprise policy, aimed at driving economic growth and sustaining better standards of living throughout Ireland. As a ‘bottom-up’ initiative, the Plans complement national level policies and programmes emanating from a ‘top-down’ such as Ireland’s national enterprise policy, Enterprise 2025 Renewed and the Future Jobs Ireland initiative. The first set of Regional Enterprise Plans to 2020 (REPs), which are currently in implementation, were launched in early 2019 and build on the success of the previous Regional Action Plans for Jobs which were in operation up to the end of 2018.The REPs provide perspective and ideas from the ‘bottom-up’. They are informed by an understanding of unique local strengths and assets and enable more effective translation of national policy into regional and local impact. Each Plan has been created by regional stakeholders who have collectively identified a number of Strategic Objectives for enterprise development for their region. The Plans complement and build on the existing activities being undertaken by the Enterprise Agencies, the LEOs and the wider range of State Bodies directly involved in supporting enterprise development in the regions, and as such, generate added value from regional and local actors working collaboratively. Nine Regional Enterprise Plan Steering Committees, chaired by private sector business people and comprising representatives of the Local Authorities, LEOs, Enterprise Ireland, IDA Ireland, Regional Skills Fora, Higher and Further Education Institutes, enterprise champions and others, oversee the implementation of the Plans. The Committees maintain the Plans as ‘live’ agendas which aim to be agile and responsive to both new opportunities and also new challenges, for example: Brexit, Climate Action, Digital Economy, and most recently, the Covid-19 pandemic economic impacts.